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Myelin Gangliosides in Vertebrates
Author(s) -
Cochran Frederick B.,
Yu Robert K.,
Ledeen Robert W.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb07959.x
Subject(s) - ganglioside , sialic acid , myelin , biology , vertebrate , biochemistry , chemistry , central nervous system , endocrinology , gene
A phylogenetic survey of brain myelin ganglioside patterns and concentrations has been carried out on 16 vertebrate species. Gangliosides were isolated from purified myelin and found to vary in concentration from 25 μg of sialic acid per 100 mg of myeh for goldfish to a value of 395 for turkey. The latter species had approximately equivalent amounts of G M1 and G M4 as the two major gangliosides. The 11 mammals studied all had G M1 as the major ganglioside, with variable amounts of G M4 ; rhesus monkey and human had 20‐25% G M4 , whereas the others had less than 10%. Amphibia and fish myelin contained the least total ganglioside, with patterns that showed relatively little G M1 and no detectable G M4 . Alligator myelin was unique in having a total concentration as high as the avian species, but a pattern with predominantly diand trisialo gangliosides.