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Regional Prostaglandin Levels in Cerebral Ischaemia
Author(s) -
Crockard H. Alan,
Bhakoo Kishore K.,
Lascelles Peter T.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb07906.x
Subject(s) - cerebral ischaemia , ischemia , prostaglandin , medicine , cardiology , neuroscience , biology
Regional quantitative studies of brain prostaglandins (PG) in gerbils with bilateral carotid ligation have shown increases in PG2 α in all areas of ischaemia but with no increases in PGE 2 . Pretreatment of animals with indomethacin (3 mg/kg) reduced this response, whereas dexamethasone (2.5 mg/kg) had no such effect. PGE 1 and thromboxane‐B 2 were found not to be present in our preparation. The significance of these findings lies in the fact that both drugs, which are known to inhibit the development of ischaemic oedema, have now been shown to produce markedly different effects on prostaglandin levels. This may indicate either, that prostaglandins are not involved in is chaemic oedema formation, or, that the drugs have different mechanisms of action.