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Chronic Alcohol Consumption Increases Cyclo (His‐Pro)‐Like Immunoreactivity in the Rat Brain
Author(s) -
Mori Masatomo,
Prasad Chandan,
Wilber John F.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb06666.x
Subject(s) - alcohol , ethanol , alcohol consumption , endocrinology , medicine , pathophysiology , alcohol intake , chemistry , central nervous system , pharmacology , biochemistry
Administration of histidyl‐proline diketopiperazine (cyclo (HisPro)) to rats attenuates ethanol‐induced sleep. To understand the role played by cyclo (His‐Pro) in the pathophysiology of prolonged alcohol consumption, we have measured the distribution of this peptide in brains of control and alcohol‐treated rats. The data show that prolonged alcohol consumption increases the concentration of cyclo (His‐Pro) in hypothalamic as well as extrahypothalamic brain. These changes may reflect a physiologic adaptation of the brain during alcohol consumption.