Premium
Regional Distribution of Neurotensin in Human Brain
Author(s) -
Manberg Paul J.,
Youngblood William W.,
Nemeroff Charles B.,
Rossor Martin N.,
Iversen Leslie L.,
Prange Arthur J.,
Kizer John S.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb06664.x
Subject(s) - neurotensin , radioimmunoassay , striatum , endocrinology , substantia nigra , human brain , hypothalamus , neuropeptide , cerebrospinal fluid , endogeny , medicine , distribution (mathematics) , chemistry , biology , neuroscience , dopamine , receptor , mathematical analysis , mathematics , dopaminergic
Neurotensin (NT) is an endogenous neuropeptide that is active in many preclinical screening tests for neuroleptic drugs. Using a radioimmunoassay, we have studied the regional distribution of NT in postmortem human brain and in cerebrospinal fluid. Highest levels were present in the hypothalamus, substantia nigra, and limbic areas, whereas much lower amounts were found in the cortex and striatum. The chromatographic properties of hypothalamic immunoreactivity on ion‐exchange and high pressure liquid chromatography were similar to those of the synthetic tridecapeptide. We conclude that NT is present in human brain with a distribution resembling that seen in other species, such as rat and monkey.