Premium
Identification and Distribution of Phenylacetic Acid in the Brain of the Rat
Author(s) -
Durden David A.,
Boulton Alan A.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb06629.x
Subject(s) - phenylacetic acid , metabolite , brainstem , caudate nucleus , cerebellum , hypothalamus , chromatography , chemistry , mass spectrometry , endocrinology , medicine , biology , biochemistry
Phenylacetic acid, the major metabolite of phenylethylamine, has been identified and quantitated in rat brain regions by capillary column high‐resolution gas chromatography mass spectrometry. Its distribution is heterogeneous and correlates with that of phenylethylamine. The values obtained were (ng/g ± SEM): whole brain, 31.2 ± 2.7; caudate nucleus, 64.6 ± 6.5; hypothalamus, 60.1 ± 7.4; cerebellum, 31.3 ± 2.9; brainstem, 33.1 ± 3.3, and the “rest,” 27.6 ± 3.0.