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Effect of Jejunoileal Bypass on Plasma and Brain Amino Acids in the Rat
Author(s) -
Herlin Per M.,
James J. Howard,
Joffe Stephen N.,
KulneffHerlin Agneta E. A.,
Fischer Josef E.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb05367.x
Subject(s) - leucine , phenylalanine , tyrosine , valine , jejunoileal bypass , shunting , endocrinology , medicine , glutamine , amino acid , tryptophan , histidine , chemistry , biochemistry , weight loss , morbid obesity , obesity
Liver failure and coma are serious complications of Jejunoileal bypass (JIB) in man. Rats underwent either a 90–95% JIB or a sham operation. Six weeks later all animals were sacrificed, and plasma and brain amino acids were determined. In the plasma of rats with JIB compared with sham operation, the concentrations of valine, leucine, isoleucine, lysine, tryptophan, and tyrosine were significantly lower, while in the brain, phenylalanine, tyrosine, histidine, and glutamine were significantly higher. These changes in the brain are similar to those resulting from portalsystemic shunting in the rat.