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Ethylenediamine as a Specific Releasing Agent of γ‐Aminobutyric Acid in Rat Striatal Slices
Author(s) -
Lloyd H. G. E.,
Perkins M. N.,
Stone T. W.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb05366.x
Subject(s) - dopamine , ethylenediamine , striatum , chemistry , gamma aminobutyric acid , aminobutyric acid , neurotransmitter , incubation , biophysics , biochemistry , endocrinology , biology , receptor , organic chemistry
Following incubation with [ 14 C]y‐aminobutyric acid (GABA) or [ 3 H]dopamine, slices of rat striatum were superfused with media containing 36 mM K + or ethylenediamine (EDA), 1 or 5 mM. Both K + and EDA induced a release of [ 14 C]GABA, the K + ‐induced release being largely Ca 2+ ‐dependent, while the EDA‐induced release was not. Whereas K + also evoked a Ca 2+ ‐dependent release of [ 3 H]dopamine, EDA evoked no release of dopamine. EDA may therefore have potential as a specific GABA releasing agent.