Premium
Uptake and Calcium‐Dependent Release of Ethylenediamine (1,2‐Diaminoethane) by Rat Brain Slices
Author(s) -
Lloyd H. G. E.,
Perkins M. N.,
Gaitonde M. K.,
Stone T. W.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb05356.x
Subject(s) - ethylenediamine , nipecotic acid , calcium , stimulation , potassium , chemistry , sodium , biophysics , medicine , biochemistry , endocrinology , biology , neurotransmitter , inorganic chemistry , receptor , organic chemistry
The uptake of [ 14 C]ethylenediamine into slices of rat brain and its subsequent evoked release have been studied. An active uptake process was demonstrated by comparing uptake at 37 and 4°C. This uptake showed a K m of 1.36 m M , was partly sodium‐dependent and was reduced by nipecotic acid. Release could be readily evoked by 30 m M potassium, and by electrical stimulation, the release in both cases being calcium‐dependent. In view of these findings and the reported interactions of ethylenediamine with γ‐aminobutyric acid‐related mechanisms, it might be of interest to determine whether this simple diamine occurs endogenously in the mammalian brain.