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Maturation of Potassium‐Stimulated Respiration in Rat Cerebral Cortical Slices
Author(s) -
Holtzman David,
Olson James,
Zamvil Scott,
Nguyen Hung
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb04734.x
Subject(s) - respiration , respiratory system , potassium , dinitrophenol , endocrinology , medicine , 2,4 dinitrophenol , chemistry , biology , biochemistry , anatomy , organic chemistry
Maximal dinitrophenol‐stimulated respiration and K + ‐stimulated respiration were measured polarographically in cerebral cortical slices taken from rats aged 2–60 days. Increasing K + concentrations produced an increase in respiration in slices from animals aged 15 days and older, but not in slices from animals aged 10 days and younger. Dinitrophenol‐stimulated respiration, or the maximal respiratory capacity of the tissue, showed a similar increase between 10 and 15 days of age. At each age the maximal respiratory capacity was 6–8 ng at 0/mg protein min greater than the maximal K + ‐stimulated respiration.