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Cyclic Nucleotides and the Release of Vasopressin from the Rat Posterior Pituitary Gland
Author(s) -
Vale Marcus R.,
Hope Derek B.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb03983.x
Subject(s) - vasopressin , posterior pituitary , medicine , endocrinology , nucleotide , cyclic nucleotide , basal (medicine) , pituitary gland , chemistry , potassium , cyclic gmp , calcium , biology , hormone , biochemistry , organic chemistry , nitric oxide , gene , insulin
When rat posterior pituitary glands were stimulated by a high concentration of potassium, a peak of cyclic AMP and a peak of cyclic GMP were detected after 0.5 min and 1 min, respectively, whereas the rate of release of vasopressin was maximal only after 2 min. When calcium was omitted from the medium, no significant changes in cyclic nucleotide levels were found and the vasopressin release remained at the basal rate. During cold‐stimulated (10°C) release of vasopressin, a peak of cyclic AMP was detected after 5 min simultaneously with the maximal rate of vasopressin release. The significance of the cyclic nucleotides in the release of vasopressin is discussed.