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Alterations of Brain Cholecystokinin Receptors in Mice Made Obese with Goldthioglucose
Author(s) -
Saito Atsushi,
Williams John A.,
Waxier Samuel H.,
Goldfine Ira D.
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb03976.x
Subject(s) - cholecystokinin , receptor , endocrinology , medicine , hypothalamus , obesity , biology , cerebral cortex , cholecystokinin receptor
We investigated the binding of cholecystokinin (CCK) to its receptors in brains of mice made obese by the injection of goldthioglucose. In these mice there was a significant increase in the number of binding sites in cerebral cortex, hypothalamus, and olfactory lobes in comparison with either unin‐jected mice or injected mice that did not become obese. The present study demonstrates, therefore, that obesity in mice is associated with changes in brain CCK receptors, and raises the possibility that obesity in certain animals may be related to abnormalities in the binding of CCK to its receptors.