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Effects of the Convulsant Methionine Sulfoximine on Striatal Dopamine Metabolism
Author(s) -
Rothstein Jeffrey D.,
Tabakoff Boris
Publication year - 1982
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1982.tb03966.x
Subject(s) - convulsant , glutamine synthetase , dopamine , glutamate receptor , chemistry , glutamine , pharmacology , metabolism , methionine , striatum , medicine , convulsants , endocrinology , biology , biochemistry , amino acid , neuroscience , anticonvulsant , epilepsy , receptor
Experiments were conducted to investigate the effects of the convulsant l ‐methionine‐ dl ‐sulfoximine (MSO) on striatal dopamine (DA) metabolism. Intraventricular injections of MSO produced a transient increase in striatal DA release followed by inhibition of DA release for up to 3 days, which paralleled the inhibition by MSO of the enzyme glutamine synthetase (GS). DA synthesis was decreased for up to 24 h after injection of MSO, but returned to normal within 3 days after MSO administration. Intrastriatal injections of MSO produced a pronounced decrease in striatal DA release and inhibition of striatal GS activity 24 h postinjection but, unlike intraventricular MSO, did not produce behavioral convulsions. Glutamate‐DA interactions may be responsible for the observed effects.