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Distribution of Catecholamines in the Ventral Mesencephalon of Human Brain, with Special Reference to Parkinson's Disease
Author(s) -
JavoyAgid F.,
Taquet H.,
Ploska A.,
CherifZahar C.,
Ruberg M.,
Agid Y.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb10843.x
Subject(s) - substantia nigra , ventral tegmental area , midbrain , dopamine , parkinson's disease , neuroscience , human brain , limbic system , tegmentum , disease , central nervous system , dopaminergic , psychology , medicine
The high levels of dopamine (DA) detected in the ventral tegmental area (VTA), as well as in the substantia nigra (SN) of human brain, suggest the presence of DA cells in these areas. This favors the possible existence of a mesocortico‐limbic system besides the mesostriatal pathway. In Parkinson's disease both DA systems seem to be deficient.