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Anesthetics Affect the Cerebral Metabolic Response to Circulatory Catecholamines
Author(s) -
Artru Alan A.,
Nugent Michael,
Michenfelder John D.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb10818.x
Subject(s) - epinephrine , norepinephrine , anesthesia , circulatory system , cyclopropane , chemistry , nitrous oxide , endocrinology , medicine , dopamine , ring (chemistry) , organic chemistry
This study examined whether the effect of intravenous infusions of either epinephrine or norepinephrine on cerebral metabolic rate for oxygen (CMR o 2 ) in the dog was modified by different anesthetics. Infusions of either epinephrine or norepinephrine at rates of 0.1‐0.25 μ kg −1 min −1 reversibly increased the CMR o 2 by 17–23% during anesthesia with cyclopropane 20% and nitrous oxide 50% in oxygen, whereas infusions at rates of 0.1‐25.0 μg‐kg −1 ‐min −1 had no effect in dogs anesthetized with other inhalational or intravenous agents. Cyclopropane/nitrous oxide also increased permeability of the blood‐brain barrier to Evan's blue dye whereas the other anesthetics tested did not. It is concluded that epinephrine and norepinephrine crossed the blood‐brain barrier during cyclopropane anesthesia, accounting for the increase in CMR o 2 . The authors speculate that cyclopropane may have increased blood‐brain barrier permeability by a direct effect on endothelial cells or by affecting central adrenergic systems and that epinephrine or norepinephrine may increase CMR o 2 either by a direct action on neuronal receptors or via metabolically coupled synaptic events.