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Thymidine Kinase Activity Is Reduced in the Developing Staggerer Cerebellum
Author(s) -
Messer Anne,
Savage Michael,
Carter Thomas P.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb06335.x
Subject(s) - thymidine kinase , mutant , thymidine , cerebellum , kinase , biology , enzyme , endogeny , nucleotide , medicine , endocrinology , biochemistry , in vitro , genetics , virus , herpes simplex virus , gene
In the mouse cerebellar mutant staggerer , thymidine kinase levels do not increase developmentally at ages when the wild‐type level is high. Mixing experiments show that this effect is not due to an endogenous inhibitor of the enzyme. Both the K m and the susceptibility of the thymidine kinase to nucleotide inhibitors are unaltered in the mutant animals, suggesting that the enzyme is not induced in the mutant.