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Effect of β‐Bungarotoxin on the Release of Endogenous Amino Acids from the Sensorimotor Cortex
Author(s) -
AbdulGhani A.S.,
CoutinhoNetto J.,
Bradford H. F.,
Summers B. A.,
Thompson E. J.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb05317.x
Subject(s) - neurotoxin , sensorimotor cortex , glutamate receptor , bungarotoxin , tetrodotoxin , endogeny , saline , chemistry , amino acid , in vivo , cerebral cortex , cortex (anatomy) , excitatory amino acid transporter , medicine , biophysics , biology , endocrinology , biochemistry , neuroscience , receptor , acetylcholine receptor , microbiology and biotechnology
β‐Bungarotoxin, a snake neurotoxin purified from the venom of Bungarus multicinctus , caused a significant increase in the in vivo release of glutamate from the superfused sensorimotor cortex of awake animals. A smaller effect on GABA release was observed, but no change was detected in the release of six other amino acids measured. The effects on glutamate and GABA release were entirely blocked by tetrodotoxin (1 μM) and were reversible when the cortical tissue was washed with saline.