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Localisation of Tricyclic Antidepressant Binding Sites on Serotonin Nerve Terminals
Author(s) -
Sette M.,
Raisman R.,
Briley M.,
Langer S. Z.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb05288.x
Subject(s) - imipramine , serotonin , dorsal raphe nucleus , tricyclic , antidepressant , chemistry , tricyclic antidepressant , hypothalamus , endocrinology , binding site , medicine , pharmacology , receptor , neuroscience , biology , biochemistry , stereochemistry , hippocampus , serotonergic , alternative medicine , pathology
High‐affinity specific [ 3 H]imipramine binding has been demonstrated in the brain and platelets of various species including man. Electrolytic lesion of the rat dorsal raphe, which resulted in a significant decrease in the endogenous levels of serotonin produced a reduction in the density of [ 3 H]imipramine binding sites in the hypothalamus and cortex. The affinity constants were unchanged. These results suggest that [ 3 H]imipramine binding sites are located on serotonin nerve terminals.