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Brain Levels of Neuron‐Specific and Nonneuronal Enolase in Huntington's Disease
Author(s) -
Marangos P. J.,
Paul S. M.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb04687.x
Subject(s) - enolase , huntington's disease , biology , basal ganglia , isozyme , pathology , degenerative disease , basal (medicine) , neuroscience , central nervous system , disease , central nervous system disease , endocrinology , medicine , immunohistochemistry , enzyme , immunology , biochemistry , insulin
— Levels of the cell‐specific brain isoenzymes of enolase were determined in basal ganglia and cerebral cortical tissue of Huntington's disease and age‐ and sex‐matched control brain. Neuron‐specific enolase (NSE) levels are decreased an average of 45% in basal ganglia from patients with Huntington's disease whereas the glial‐specific form of enolase, nonneuronal enolase (NNE), is not significantly altered. In contrast, levels of NSE in cerebral cortical tissue from Huntington's disease patients remains unchanged in comparison with controls whereas NNE levels are significantly increased. NNE and NSE levels appear to be specific biochemical indicators of glial and neuronal cell number and viability. Levels of these cell‐specific isoenzymes may therefore prove useful in quantitating neuropathological changes in various neurological disorders.