Premium
Developmental Changes of N‐Acetyl‐L‐Aspartic Acid, N‐Acetyl‐α‐Aspartylglutamic Acid and β‐Citryl‐L‐Glutamic Acid in Different Brain Regions and Spinal Cords of Rat and Guinea Pig
Author(s) -
Miyake Masaharu,
Kakimoto Yasuo
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb04500.x
Subject(s) - guinea pig , glutamic acid , cerebellum , aspartic acid , spinal cord , medicine , cerebrum , endocrinology , biology , chemistry , central nervous system , biochemistry , amino acid , neuroscience
The developmental changes of N ‐acetylaspartic acid (NA‐Asp), N ‐acetyl‐α‐aspartylglutamic acid (NA‐Asp‐Glu), and β ‐citryl‐L‐glutamic acid ( β ‐CG) have been examined in the cerebrum, cerebellum, brain stem and spinal cord of both rat and guinea pig by the gas chromatographic method developed in our studies. A rapid increase in the concentration of NA‐Asp was observed postnatally in every region of the rat brain. On the other hand, all regions of guinea pig brain showed the prenatal increases. NA‐Asp‐Glu showed a different developmental profile, depending on region of the brain, in the two species. The concentration of NA‐Asp‐Glu remained constantly low during brain maturation in the rostral regions. In the caudal portions it showed a marked increase during maturation and reached a high level in the adult brain. The concentration of β ‐CG was highest at birth in all regions of rat brain and rapidly decreased by 20 days after birth and remained low thereafter. The rapid decrease occurred in the guinea pig during the foetal period, and β ‐CG content decreased to an adult level at birth.