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Control of Noradrenaline Release from Hippocampal Synaptosomes
Author(s) -
West D. P.,
Fillenz M.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb04496.x
Subject(s) - tranylcypromine , hippocampal formation , potassium , chemistry , pulse (music) , synaptosome , liberation , endocrinology , biophysics , medicine , biology , biochemistry , enzyme , monoamine oxidase , physics , organic chemistry , detector , membrane , optics , in vitro
Potassium‐evoked tritiated noradrenaline (NA) release from hippocampal synaptosomes was measured with a superfusion method. A single 2‐min high‐K + pulse released 39% of the vesicular NA by a Ca 2+ ‐dependent mechanism; the Ca 2+ ‐independent release was negligible. After changing the vesicular NA store size by pretreating rats with either α‐methyl‐para‐tyrosine, 500 mg/kg, or tranylcypromine, 10 mg/kg, a single K + pulse released a constant percentage of the vesicular NA. With two K + pulses, however, there was a reduction in the percentage of vesicular N A released in response to the second pulse.
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