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Blood‐Brain Glucose Transfer in Spreading Depression
Author(s) -
Gjedde Albert,
Hansen Anker Jón,
Quistorff Bjørn
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb04465.x
Subject(s) - cortical spreading depression , cerebral blood flow , blood flow , glucose transporter , medicine , endocrinology , cortex (anatomy) , carbohydrate metabolism , cerebral cortex , glucose uptake , chemistry , biology , neuroscience , insulin , migraine
Spreading depression in rat brain cortex is associated with a twofold increase of cerebral blood flow. It is not known whether this increase is coupled to increases of cerebral metabolic rate and glucose transport from blood to brain. During the passage of a single spreading depression, we measured blood‐brain glucose transport and glucose metabolism in rat cerebral cortex by single intravenous injection of tracer glucose. Blood flow and tissue content of glucose were measured as well. Reduction of tissue glucose and the consequent increase of net transfer of glucose from blood to brain were consistent with a threefold increase of the consumption of glucose before the increase of blood flow. There was no increase of unidirectional blood‐brain transfer.