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Inhibition by Neurotoxic Phospholipases A 2 of Synaptosomal Uptake of γ‐Aminobutyric Acid
Author(s) -
Ng Ronald H.,
Howard Bruce D.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb02412.x
Subject(s) - phospholipase a2 , aminobutyric acid , phospholipase , phospholipase a , enzyme , synaptosome , chemistry , biochemistry , gamma aminobutyric acid , cerebral cortex , pharmacology , biology , endocrinology , in vitro , receptor
A comparison has been made of the abilities of several neurotoxic and nontoxic phospholipases A 2 from snake venoms to inhibit the intake of γ‐aminobutyric acid into synaptosomes from rat cerebral cortex. The neurotoxic phospholipases A 2 inhibited GABA uptake more than the nontoxic enzymes did. However, there was a poor correlation between the measured specific enzyme activity of a phospholipase A 2 and its ability to inhibit the uptake of GABA.