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Distribution of Protein I, a Synapse‐Specific Phosphoprotein, and Adenylate Cyclase in the Rat Spinal Cord
Author(s) -
Ueda Tetsufumi,
Stratford Carol A.,
Larson James
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb02407.x
Subject(s) - adenylate kinase , cyclase , phosphoprotein , spinal cord , synapse , biology , phosphorylation , endocrinology , microbiology and biotechnology , neuroscience , chemistry , biochemistry , stimulation , receptor
The longitudinal and transverse distributions of the synapse‐specific phosphoprotein Protein I and adenylate cyclase in the rat spinal cord were studied. Protein I was found to be enriched in all cervical and midlumbar (L 3 ‐L 5 ) segments, and sparse in midthoracic and sacral segments. Adenylate cyclase activity was high in all cervical and lumbosacral segments, and low in mid‐thoracic segments. Cross‐sectionally, both Protein I and adenylate cyclase were more enriched in the dorsal half than in the ventral half in the various segments studied. The similar topographical distributions of Protein 1 and adenylate cyclase in the spinal cord support the idea that adenylate cyclase may be intimately associated with Protein I in the nervous system, and could thereby regulate the state of in vivo phosphorylation of Protein I through formation of cyclic AMP.