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Changes in Rabbit Brain Cytosolic and Membrane‐Bound Gangliosides During Prenatal Life
Author(s) -
Sonnino Sandro,
Ghidoni Riccardo,
Masserini Massimo,
Aporti Franco,
Tettamanti Guido
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb02398.x
Subject(s) - ganglioside , cytosol , pregnancy , membrane , period (music) , biochemistry , biology , chemistry , endocrinology , enzyme , genetics , physics , acoustics
The present study deals with the developmental profile of cytosolic and membrane‐bound gangliosides in rabbit whole brain from the 21st day of pregnancy, the time at which brain could be macroscopically recognized and handled, till birth. In this period of prenatal life the content of membrane‐bound gangliosides showed a 2.5‐fold increase, referred to fresh and dry brain weight and to membrane‐bound protein; the content of cytosolic gangliosides reached a maximum at 21‐22 days of pregnancy, and then underwent to birth a threefold diminution. The qualitative pattern of membrane‐bound gangliosides, in the same period of life, was characterized by an increase of G D1a and G M1 (more marked for G D1a ), a decrease of G T1a , G T1b and G Q1b and a constant level of G D3 and G D1b . At 21 days of pregnancy the most abundant gangliosides were G T1b , and G Q1b , followed by G D1a and G D1b ; at birth it was G D1a followed by G T1b G D1b , and G M1 The qualitative pattern of cytosolic gangliosides closely resembled, during the entire period of prenatal life examined, that of membrane‐bound gangliosides.