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Antagonism of Excitatory Amino Acid‐Induced and Synaptic Excitation of Spinal Neurones by cis ‐2,3‐Piperidine Dicarboxylate
Author(s) -
Davies J.,
Evans R. H.,
Francis A. A.,
Jones A. W.,
Watkins J. C.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb01736.x
Subject(s) - antagonism , excitatory postsynaptic potential , long term potentiation , kainate receptor , nmda receptor , excitatory amino acid antagonists , agonist , chemistry , biology , neuroscience , acetylcholine , ampa receptor , pharmacology , receptor , inhibitory postsynaptic potential , biochemistry
In tests on neurones in the cat spinal cord in vivo , and frog and immature rat spinal cord in vitro , cis ‐2,3‐piperidine dicarboxylate ( cis ‐2,3‐PDA) produced the following effects: (1) selective antagonism of amino acid‐induced responses, compared with responses to other putative transmitters; (2) effective antagonism of kainate and quisqualate‐induced responses in addition to responses induced by N ‐methyl‐D‐aspartate (NMDA) and other excitatory amino acids; (3) partial NMDA‐like agonist action; (4) antagonism of dorsal root‐evoked excitation of Renshaw cells; (5) potentiation of acetylcholine‐ and ventral root‐evoked excitation of Renshaw cells. This unique spectrum of action may be useful for transmitter receptor characterization in the vertebrate central nervous system.