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Sulfur Amino Acid Metabolism in the Developing Rhesus Monkey Brain: Subcellular Studies of the Methylation Cycle and Cystathionine β‐Synthase
Author(s) -
Rassin David K.,
Sturman John A.,
Gaull Gerald E.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb01726.x
Subject(s) - cystathionine beta synthase , biochemistry , serine hydroxymethyltransferase , homocysteine , methylation , methionine , serine , glycine , biology , metabolism , amino acid , enzyme , chemistry , gene
The subcellular distributions of the enzymes associated with the methylation and cystathionine‐synthesizing portion of the sulfur amino acid metabolic pathway have been determined in the occipital lobe of the rhesus monkey. 5‐Methyltetrahydrofolate‐homocysteine methyltransferase and 5, 10‐methylenetetrahydrofolate reductase activities are located mainly in the soluble compartment. Serine hydroxymethyltransferase activity is located primarily in mitochondria. Cystathionine β‐synthase is a soluble enzyme with a significant component occluded within the nerve endings. Glycine, serine, and cystathionine increase per gram of tissue during development. Glycine and serine are approximately 30% occluded within the nerve endings. These data are consistent with a localization of sulfur amino acid metabolism that supports a differential compartmentation of potential neurotransmitter function and methylation function in the primate.