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Effect of Inorganic Lead on Rat Brain Mitochondrial Respiration and Energy Production
Author(s) -
Gmerek Debra E.,
McCafferty Mary R.,
O'Neill Kevin J.,
Melamed Brian R.,
O'Neill John J.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb01706.x
Subject(s) - respiration , lead (geology) , energy metabolism , chemistry , mitochondrion , biochemistry , biology , endocrinology , anatomy , paleontology
Toxicologically significant amounts of inorganic lead were added to rat brain mitochondrial preparations that did not contain EDTA or P i . The binding of the lead to the mitochondria was measured by anodic stripping voltometry. In the presence of lead, the respiratory control ratios decreased, implying a decrease in the degree of dependence of respiration on a phosphate acceptor. Nucleotide contents were also measured, and in the presence of inorganic lead the actual amounts of ATP formed from ADP were found to be significantly decreased as well.