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Structure of Bovine P 2 Basic Protein: Sequence of a Carboxyterminal Segment That Is a Neuritogen in Rabbits
Author(s) -
Hsieh D. L.,
Weise M. J.,
Levit S.,
Powers J. M.,
Brostoff S. W.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb01681.x
Subject(s) - sequence (biology) , chemistry , biology , biochemistry
The sequence of the carboxyterminal 18 amino acids released by cyanogen bromide digestion of the bovine P 2 protein was determined. It has several interesting structural and immunological properties. It contains the only two half‐cystines in the molecule that have the capacity to form an intrachain disulfide bond. Using the rabbit as a test animal, this carboxyterminal peptide was capable of producing experimental allergic neuritis. The sequence of this peptide is Val‐Val‐Glu‐Cys‐Lys‐Met‐Lys‐Asp‐Val‐Val‐Cys‐Thr‐Arg‐Ile‐Tyr‐Glu‐Lys‐Val.