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Metabolite Alterations in the Genetically Spastic Mouse
Author(s) -
Stewart James A.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb01658.x
Subject(s) - arginase , arginine , metabolite , medicine , endocrinology , urea , enzyme , amino acid , biology , chemistry , biochemistry
The concentration of soluble amino acids in the brains of homozygous spastic mice was measured. It was found that brain arginine levels were reduced by 3% and urea concentration was 50% higher in affected mice. The activity of the brain and liver enzymes for arginine synthesis were similar in spastics and in controls. However, in spastic mice the activity of brain arginase is elevated. This increased arginase activity accounts for the decreased arginine concentration in the mutant mice.