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Metabolism of Acetate to Amino Acids in Brains of Rats After Complete Hepatectomy
Author(s) -
Tyce Gertrude M.,
Ogg Jauneita,
Owen Charles A.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb01637.x
Subject(s) - glutamine , hepatectomy , glutamate receptor , metabolism , medicine , amino acid , biochemistry , chemistry , endocrinology , biology , surgery , resection , receptor
The concentration of glutamine increases in the brain after hepatectomy. In the present studies the conversion of intravenously given [ 14 C]acetate to [ 14 C]glutamate and [ 14 C]glutamine was studied in control rats and in rats at 6 h after complete hepatectomy. The incorporation of label into glutamate was only slightly inhibited, but the further incorporation into glutamine was greatly inhibited, after hepatectomy. These data, and previous data using [ 14 C]glucose as precursor, indicate that synthesis of glutamine in brain is inhibited after hepatectomy, and suggest that its concentration must increase because degradation is inhibited to an even greater extent.