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Effect of Undernutrition on Tryptophan and Tyrosine Hydroxylases in the Developing Rat Brain
Author(s) -
Kalyanasundaram S,
Ramanamurthy P. S. V
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb00601.x
Subject(s) - tryptophan , tyrosine , malnutrition , chemistry , biology , medicine , neuroscience , biochemistry , amino acid
Rats born to well‐fed mothers (20% protein diet ad libitum) , protein‐restricted mothers (7.5% protein diet ad libitum) or pair‐fed with protein‐restricted mothers were killed on days 0, 7, 14, 21, 28 and 35 and activities of the two enzymes of neurotransmitter synthesis, tryptophan‐5‐hydroxylase (EC 1.14.16.4) and tyrosine hydroxylase (EC 1.14.16.2) were assayed. Enzyme activities in normal animals were low at birth and progressively increased to reach adult levels by day 15. Protein‐restricted and pair‐fed animals also showed a similar pattern. However, significantly higher activities were observed from day 15 onwards in both experimental groups.