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Characterisation of Inhibitory 5‐Hydroxytryptamine Receptors That Modulate Dopamine Release in the Striatum
Author(s) -
Ennis Christine,
Kemp Janet D,
Cox Barry
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb00594.x
Subject(s) - dopamine , striatum , inhibitory postsynaptic potential , dopamine receptor , receptor , neuroscience , chemistry , pharmacology , biology , biochemistry
The effect of a series of indoleamines on the potassium‐evoked tritium release of previously accumulated [ 3 H]dopamine from rat striatal slices has been investigated. The indoleamines 5‐hydroxytryptamine, 5‐methoxy‐tryptamine, 5‐methoxy‐ N, N′ ‐dimethyltryptamine and tryptamine (10 −7 to 10 −3 M) all reduced potassium‐evoked release of tritium, to a maximum of 50%. The uptake of [ 3 H]dopamine was unaffected by these compounds. A series of 5‐hydroxytryptamine antagonists were examined for their ability to reduce the inhibition of potassium‐evoked tritium release induced by 5‐methoxytryptamine. The relative order of antagonist potency obtained was methysergide > metergoline > methiothepin > cinanserin > cyproheptadine > mianserin, and was consistent with an action on 5‐hydroxytryptamine receptors. It is concluded that there are inhibitory 5‐hydroxytryptamine receptors located on the terminals of dopaminergic neurones in the striatum.