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Glutathione‐ S ‐Transferase Activity in the Brain: Species, Sex, Regional, and Age Differences
Author(s) -
Das Mukul,
Dixit Rakesh,
Seth Prahlad K,
Mukhtar Hasan
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb00584.x
Subject(s) - glutathione , glutathione s transferase , glutathione transferase , biology , transferase , biochemistry , enzyme
Glutathione‐ S ‐transferase activity in the brain of male mammals (rat and mouse) was found to be relatively lower than in that of females. In contrast, the male aves (pigeon, kite, vulture, and crow) exhibited comparatively higher activity of brain glutathione‐ S ‐transferase than the corresponding females. Postnatal development of cytosolic glutathione‐S‐transferase activity in the rat brain was also investigated. The day‐7 rats showed a low activity of 48 nmol/min/mg protein that gradually increased 3.2‐fold over the age of 28 days. No striking differences in brain enzyme activities were observed between the 35‐ and 90‐day‐old rats. Discrete brain regions of immature rats were found to possess considerable but lower quantities of glutathione‐ S ‐transferase activity than those of the adults. The activity increased with the onset of development and attained a steady state after 21 days of age.