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Ontogeny of Receptor Binding Sites for [ 3 H]Glutamic Acid and [ 3 H]Kainic Acid in the Rat Cerebellum
Author(s) -
Slevin J. T.,
Coyle J. T.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb00491.x
Subject(s) - kainic acid , synaptogenesis , kainate receptor , cerebellum , glutamatergic , glutamate receptor , glutamic acid , biology , binding site , ontogeny , biochemistry , receptor , medicine , endocrinology , chemistry , neuroscience , biophysics , amino acid , ampa receptor
The development of the specific binding sites for l ‐[ 3 H]glutamic acid ( K D = 370 nM) and for [ 3 H]kainic acid ( K D = 39 nM) was studied in the rat cerebellum. Specific binding at both sites remains low during the first week after birth but increases markedly during the second and third weeks after birth, when glutamatergic parallel fiber synaptogenesis occurs. The development of the kainate site lags behind that of the glutamate site, indicating their autonomy.