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Substantia Nigra γ‐Aminobutyric Acid Receptors in Huntington's Disease
Author(s) -
Cross Alan J.,
Waddington John L.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb00458.x
Subject(s) - substantia nigra , kainic acid , lesion , gamma aminobutyric acid , receptor , gabaa receptor , medicine , neuroscience , aminobutyric acid , striatum , endocrinology , biology , chemistry , disease , parkinson's disease , pathology , dopamine , glutamate receptor
The specific binding of [ 3 H]γ‐aminobutyric acid (GABA) to nigral GABA receptors has been studied in postmortem brains from controls and patients with Huntington's disease (HD). A specific increase in the number of high‐affinity binding sites for [ 3 H]GABA was observed in HD patients, analogous to changes observed in rat substantia nigra [ 3 H]GABA binding after striatal kainic acid (KA) lesion. The results provide further support for the striatal KA lesion in the rat as an animal model of HD. The implications of the results for the proposed therapeutic potential of GABA agonists in HD are discussed.