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Enhancement of 45 Ca 2+ Binding to Acidic Lipids by Barbiturates, Diphenylhydantoin, and Ethanol
Author(s) -
Chweh A. Y.,
Leslie S. W.
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb00443.x
Subject(s) - phosphatidic acid , phosphatidylserine , chemistry , cardiolipin , ethanol , hexobarbital , phosphatidylethanolamine , phosphatidylinositol , biochemistry , phospholipid , phosphatidylcholine , in vitro , microsome , kinase , membrane
Effects of barbiturates, diphenylhydantoin, and ethanol on 45 Ca 2+ binding to acidic lipids have been examined in an organic solvent‐aqueous partition system. Hexobarbital, pentobarbital, and phenobarbital, at concentrations of 0.3 and/or 0.6 mM, enhanced the binding of 45 Ca 2+ to phosphatidic acid, phosphatidylserine, and sulfatide but not to phosphatidylinositol or cardiolipin. Diphenylhydantoin, 0.3 mM, enhanced 45 Ca 2+ binding to phosphatidic acid and phosphatidylserine but not to sulfatide. Ethanol at 80 mM did not enhance 45 Ca 2+ binding to phosphatidic acid, but ethanol decreased the binding to cardiolipin and increased it to sulfatide.