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Effect of Changing Potassium Ion Concentrations on Rat Cerebral Slices In Vitro : A Study During Development
Author(s) -
Grisar Thierry,
Franck Georges
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb00440.x
Subject(s) - potassium , cerebral cortex , carbonic anhydrase , in vitro , chemistry , endocrinology , medicine , atpase , cortex (anatomy) , biology , biochemistry , neuroscience , enzyme , organic chemistry
Adult rat cerebral cortex slices when incubated in media of increasing K + concentrations, from 3 to 20 mM (“physiological” conditions), exhibited an increase of K i + and a decrease of Na i + and Cl i ‐ . This phenomenon appeared at 30 days postnatally, which is fairly late during development. Over 20 mM‐K + (“pathological” conditions) an intense water uptake was observed together with an increase of Na i + and Cl i ‐ . This was observed in both adult and young animals. The results are discussed in relation to the well known properties of glial (Na + ,K + )‐ATPase and carbonic anhydrase.