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Presence of Protein I, a Phosphoprotein Associated with Synaptic Vesicles, in Cerebellar Granule Cells
Author(s) -
Dolphin Annette C.,
Greengard Paul
Publication year - 1981
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1981.tb00412.x
Subject(s) - synaptic vesicle , phosphoprotein , granule (geology) , chemistry , neuroscience , vesicle , cerebellum , microbiology and biotechnology , biology , biochemistry , phosphorylation , membrane , paleontology
The cerebellar levels of Protein I, a synapse‐specific neuronal phosphoprotein, have been investigated in the cerebellar mouse mutants staggerer ( sg ), weaver ( wv ), nervous ( nr ), and Purkinje cell degeneration ( pcd ). The Protein I concentration was reduced by about 66% in sg and wv mutants, representing a 90% loss of Protein I per cerebellum. A heterozygote effect was observed in the wv mutant. These results indicate that a great majority of Protein I in the normal cerebellum may be present in the granule cells. in nr mutants the cerebellar Protein I concentration was reduced by only 12% in 62‐day‐old mice, suggesting that Purkinje cells contribute little to cerebellar Protein I. However, a greater reduction was observed in pcd mutants, which may reflect on the nature of the pcd mutation.