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Ontogenetic Development of Histamine H 1‐ Receptor Binding in Rat Brain
Author(s) -
Tran Vinh Tan,
Freeman Andrew D.,
Chang Raymond S. L.,
Snyder Solomon H.
Publication year - 1980
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1980.tb11251.x
Subject(s) - mepyramine , histamine , histidine decarboxylase , receptor , biology , medicine , endocrinology , histamine receptor , biochemistry , histidine , chemistry , enzyme , antagonist
Abstract: Histamine H 1‐ receptors labeled with [ 3 H]mepyramine in rat brain show an age‐dependent development. [ 3 H]Mepyramine receptor density and histidine decarboxylase activity in whole rat brain reach adult levels at 25–30 days after birth and they attain 50% of adult level at day 10 and 17, respectively. The apparently later development of histidine decarboxylase activity in whole rat brain is partly accounted for by a biphasic developmental increase of this enzymatic activity in cerebral cortex. For all other brain regions examined, the development of histamine H 1‐ receptors parallels that of histidine decarboxylase. The increase in [ 3 H]mepyramine binding can be accounted for by an absolute increase in the numbers of the receptor sites, with no change in affinity. Subcellular fractionation studies indicate that histamine H 1‐ receptors are predominantly associated with synaptosomal fractions derived from both newborn and adult rat.