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Changes in Glycoprotein Metabolism in the Cerebral Cortex Following First Exposure of Dark‐reared Rats to Light
Author(s) -
Burgoyne Robert D.,
Rose Steven P. R.
Publication year - 1980
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1980.tb11174.x
Subject(s) - fucose , visual cortex , cortex (anatomy) , cerebral cortex , biology , biochemistry , medicine , endocrinology , motor cortex , chemistry , glycoprotein , neuroscience , stimulation
The level of incorporation of [ 3 H]fucose or [ 3 H]lysine into subcel‐lular fractions of the visual and motor cortices of 50‐day‐old dark‐reared (D) and light‐exposed (L) rats was determined. No differences were found between D and L rats in the incorporation of either precursor into subcellular fractions of the motor cortex, or in any fraction of the visual cortex except the synaptic‐membrane fraction. After a 3‐h light exposure the incorporation of [ 3 H]fucose into the visual cortex synaptic‐membrane fraction was elevated (L/D = 136%). Incorporation of [ 3 H]lysine was elevated in the visual cortex synaptic‐membrane fraction of L compared to D rats after a 1‐h exposure (L/D = 118%). However, after a 3‐h exposure the incorporation was depressed in this fraction (L/D = 79%). No differences could be found in the levels of activity of fucosyl transferase following first exposure to light but dark‐rearing itself resulted in increased enzyme activity in the motor cortex compared to normal controls. First exposure of 20‐day‐old dark‐reared rats to light led to an increase in the incorporation of [ 3 H]fucose into soluble glycoproteins of both the visual and motor cortex and into particulate glycoproteins of the visual cortex only. These results are in contrast with those found with 50‐day‐old animals and suggest that the effects of light‐exposure on [ 3 H]fucose incorporation may be age‐dependent.