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Similarities Between A.P.U.D. Cells and Monoaminergic Neurons: Evidence for a Dopamine Uptake Mechanism in C Cells of Chicken Ultimobranchial Gland
Author(s) -
Lauro A.,
Popoli M.,
Campanella G.,
Avati U.
Publication year - 1980
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1980.tb11173.x
Subject(s) - monoaminergic , dopamine , dopaminergic , neurotransmitter , incubation , medicine , endocrinology , neural crest , biology , microbiology and biotechnology , chemistry , biochemistry , serotonin , embryo , central nervous system , receptor
The uptake of [ 3 H]dopamine was studied in the C cells of chicken ultimobranchial gland (UBG). DA uptake appears to be an active and saturable mechanism (K m = 8.6 μM). The C cells' affinity for DA is intermediate between dopaminergic synaptosomes and such extraneural tissues as platelets and heart. UBG incubation with DA leads to the synthesis of a noticeable quantity of DOPAC, indirectly showing the presence of MAO activity. Thus UBG C cells, besides having both an embryological derivation from the neural crest and some morphological aspects similar to synaptosomes, also possess an active uptake mechanism for a central neurotransmitter.