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A Prolactin Action on Acetylcholine Metabolism in Striatum, Hippocampus, and Thalamus
Author(s) -
Wood Paul L.,
Cheney D. L.,
Costa E.
Publication year - 1980
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1980.tb09938.x
Subject(s) - striatum , dopaminergic , acetylcholine , hippocampus , dopamine , neuroscience , medicine , thalamus , endocrinology , prolactin , cholinergic , hippocampal formation , biology , chemistry , hormone
Since prolactin can regulate the release of striatal dopamine, we have evaluated the functional implications of this effect by studying the action of injected prolactin on the turnover rate of acetylcholine (TR ACh ) in various brain areas. We selected striatum and hippocampus as two areas in which dopaminergic terminals are known to regulate TR ACh and frontal and parietal cortex as areas where dopamine has little or no control on TR Ach . Intraventricularly injected prolactin reduces the TR ACh in striatum, hippocampus, and thalamus but not in the two cortical areas. Intraseptal injection of prolactin reduces TR ACh in hippocampus, suggesting that this polypeptide acts on hippocampus by changing the activity of afferent neurons impinging upon the cell bodies of the cholinergic septal‐hippocampal neurons. The reductions in TR ACh induced by intraventricular prolactin in hippocampus and striatum are nullified by 6‐hydroxydopamine‐induced lesions of dopaminergic neurons located in areas A 9 and A 10 . These results suggest that the presence of dopaminergic neurons is required to obtain the prolactin‐elicited decrease of TR Ach .