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Effect of Cerebellar Lesions on Monoamine Levels in Various Brain Areas of the Cat
Author(s) -
Cano J.,
GarciaUria J.,
Machado A.,
ReinosoSuarez F.
Publication year - 1980
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1980.tb09021.x
Subject(s) - monoamine neurotransmitter , cerebellar vermis , thalamus , cerebellum , hippocampus , neuroscience , cerebellar cortex , caudate nucleus , cortex (anatomy) , biology , medicine , serotonin , receptor
Modifications in the content of monoamines after different lesions of the cerebellar cortex were investigated in eight prosencephalic structures of cat's brain. Apart from other minor changes, lesions of the posterior vermis induced significant changes in the thalamus (decrease of DA and increase of 5‐HT). Lesions of the cortex of a cerebellar hemisphere, on the other hand, produced an increase of 5‐HT in the caudate nucleus and an increase of DA in the hippocampus in addition to a generalized increase of 5‐HT in all the prosencephalic structures studied. These findings are discussed in relation to the anatomical connections of the lesioned areas and their expected role in the sleep‐wakefulness cycle.