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Pentobarbital Anesthesia Reduces Blood–Brain Glucose Transfer in the Rat
Author(s) -
Gjedde Albert,
Rasmussen Mette
Publication year - 1980
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1980.tb09013.x
Subject(s) - pentobarbital , blood flow , chemistry , endocrinology , medicine , cerebral blood flow , arterial blood , anesthesia , glucose transporter , insulin
Pentobarbital anesthesia (40 mg kg –1 ) was accompanied by a 50% decrease of blood flow and a 40% decrease of unidirectional blood‐brain glucose transfer in the parietal cortex of the rat brain. The correlation was explained by a decrease of the number of perfused capillaries. The maximal transport capacity, T max , decreased from 409 to 235 μ mol 100 g –1 min –1 and the half‐saturation constant, K m , from 8.8 to 4.9 mm. At 8.3–8.7 m m ‐glucose in arterial plasma, the transfer constant (clearance) for unidirectional blood‐brain transfer decreased from 0.195 ± 0.011 in awake rats to 0.132 ± 0.005 ml g –1 min –1 in anesthetized rats. Half of the decrease was due to less complete diffusion‐limitation of glucose uptake at the low plasma flow rate in brain, the other half to the decreased T max .