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Elevation of Substance P‐like Immunoreactivity in Rat Central Nervous System by Protease Inhibitors
Author(s) -
Hanson Glen R.,
Lovenberg Walter
Publication year - 1980
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1980.tb09011.x
Subject(s) - substance p , leupeptin , central nervous system , protease , medicine , endocrinology , biology , chemistry , pharmacology , enzyme , neuropeptide , biochemistry , receptor
Abstract: Several substance P‐rich areas in rat CNS had increased levels of substance P‐like immunoreactivity following the intraventricular injection of the protease inhibitors SQ 20881, SQ 14225, and leupeptin. There were significant differences in response patterns from region to region, possibly on account of an interaction of anatomical, biochemical, or physiological variables. Although the compound SQ 14225 appeared to be the most potent of the inhibitors examined, it had no apparent effect on CNS substance P‐like immunoreactivity when administered peripherally.