Premium
Cyclic AMP Enhancement of Depolarization‐Induced NAD(P)H Changes in Brain Cortical Slices
Author(s) -
Keller E.,
Cummins J. T.
Publication year - 1980
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1980.tb09006.x
Subject(s) - depolarization , nad+ kinase , basal (medicine) , chemistry , biophysics , medicine , endocrinology , substrate (aquarium) , biology , biochemistry , enzyme , ecology , insulin
The increased levels of NAD(P)H effected by electrical depolarization are markedly augmented in the presence of cyclic AMP, isoproterenol, or RO 20–1724, agents known to elevate cyclic AMP in rat brain slices. The data presented indicate that the cyclic AMP effect on an important component of intermediate metabolism is not an enhancement of a basal response but a separate response that is activated by depolarization, is Ca 2+ –dependent, regulates cytochrome a‐a 3 independently of its effects on NAD(P)H levels, and is dependent on a substrate other than glucose.