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Effect of Capsaicin Pretreatment on Substance P Binding to Synaptic Vesicles
Author(s) -
Mayer N.,
Gamse R.,
Lembeck F.
Publication year - 1980
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1980.tb07881.x
Subject(s) - capsaicin , substance p , spinal cord , synaptic vesicle , vesicle , chemistry , medicine , degeneration (medical) , dorsum , neuropeptide , endocrinology , neuroscience , biology , biochemistry , anatomy , receptor , pathology , membrane
Newborn or adult rats were pretreated with 50 mg kg –1 capsaicin. At the age of 2 to 4 months, binding of 125 1‐labelled Tyr 8 ‐substance P to synaptic vesicles prepared from different regions of the nervous system was examined. In both groups, capsaicin pretreatment led to a significant decrease in the number of binding sites in dorsal roots and spinal cord without having an effect on affinity. This decrease parallels the depletion of the substance P content (Gamse et al., 1980) and can be explained by degeneration of primary sensory neurons in newborn treated rats and by depletion of vesicles in adult treated rats.