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Lysosomal Acid Hydrolases in Developing Huml Brain Regions
Author(s) -
Sinha L.,
Sinha A. K.
Publication year - 1980
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1980.tb07861.x
Subject(s) - midbrain , cerebellum , medulla , acid phosphatase , spinal cord , endocrinology , medicine , biology , central nervous system , ontogeny , human brain , cortex (anatomy) , phosphatase , enzyme , chemistry , biochemistry , neuroscience
β‐D‐Glucosidase, β‐D‐glucosaminidase, acid phosphatase, and β‐D‐galactosidase were monitored in the human foetal brain at different gestaional periods. Glucosidase specific activity in all brain regions exhibits two peaks, at 8 g and 32 g foetal weights. Acid phosphatase exhibits very high specific activity in all brain regions at 5 g, but the cerebellar activity forms a peak at 220 g foetal weight, the midbrain at 135 g, and the spinal activity at 760 g. β‐D‐Glucosaminidase has a peak at 220 g and 660 g in the midbrain, and β‐D‐galactosidase specific activity is highest in the cortex and cerebellum in late gestation (neuronal differentiation phase). The midbrain medulla and the spinal cord show peak activity at 8 g and 220 g foetal weight. The results suggest an inter‐ and intraregional heterogeneity of acquisition for these enzymes in human brain ontogeny.