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Regional Distribution of Glutathione Peroxidase in the Adult Rat Brain
Author(s) -
Brannan Timothy S.,
Maker Howard S.,
Weiss Cipora,
Cohen Gerald
Publication year - 1980
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1980.tb07102.x
Subject(s) - glutathione peroxidase , distribution (mathematics) , peroxidase , neuroscience , glutathione , chemistry , biochemistry , biology , enzyme , mathematics , mathematical analysis
Glutathione peroxidase activity was measured in 10 areas of perfused adult rat brain with the use of a fluorometric assay coupled to NADPH oxidation. The caudate‐putamen and the substantia nigra had the highest activities. Cortical areas and several nuclear areas had somewhat lower activity. Activity was lowest in a white matter structure (corpus callosum). High activity of glutathione peroxidase may be related to the need to reduce hydrogen peroxide arising in the course of monoamine metabolism.