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Thiamin Deficiency in the Lamb: Changes in Thiamin Phosphate Esters in the Brain
Author(s) -
Thornber E. J.,
Dunlop R. H.,
Gawthorne J. M.
Publication year - 1980
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1980.tb03710.x
Subject(s) - thiamine , thiamine deficiency , medicine , endocrinology , cortex (anatomy) , chemistry , white matter , cerebral cortex , brain cortex , biology , biochemistry , neuroscience , radiology , magnetic resonance imaging
: Concentrations of thiamin (unphosphorylated), thiamin monophosphate (TMP), thiamin diphosphate (TDP), and thiamin triphosphate (TTP) were measured in three regions of the brain of seven pairs of lambs. The lambs were maintained on a thiamin‐free synthetic diet for 2, 3, or 4 weeks. Controls were pair‐fed and supplemented with thiamin. The three brain regions were: (1) dorso‐lateral aspect of the cortex [common site for lesions of polioencephalomalacia (PEM)]; (2) pyriform lobe of the cortex (no PEM lesions are found here); (3) white matter of the internal capsule (no PEM lesions found here). The concentration of TTP in all three sections of brain was maintained at control values for up to 4 weeks on the thiamin‐deficient diet. TDP concentration decreased to 22% of control values in both regions of grey matter after 4 weeks on the diet. Unphosphorylated thiamin and TMP decreased to a smaller extent than TDP.